I've been kind of following the whole gender-tagging war here on e621, and to be honest, people just need to chill out. TWYS has been the rule forever (or for at least as long as I've been a member), but people are bringing their SJW BS here, and I'm done reading about it on almost every post marked ambiguous_gender.

There are a few people I would just like to block, but I don't know how to add them to my blacklist. Does anyone know how to do this?

C&P from the blacklist wiki page:

Specific Users
In other cases you may find that you dislike everything that a specific user uploads. Some people upload many different types of images, while others upload according to a theme. Some users are not as picky as others regarding their uploads. If you find that you dislike the majority of a user's uploads, and wish that you could not see any uploads from them at all, you can blacklist specific users:

user:ilovegoreandblood
user:mangafanatic
user:bobmcfurryson

And, in your settings is an option to apply this to forums and etc.

Nikolaithefur said:
There are a few people I would just like to block, but I don't know how to add them to my blacklist. Does anyone know how to do this?

Add them to your blacklist using the line "user:" (without the quotes) followed by the name of the user you want blocked.

Yeah what they said