I am wondering if there is a way to make so that when I search, I don't filter out things I do want, with things I don't.

For example, I don't want videos that are 'male+solo' but I do want videos that have either males, or solo females.

Another thing, is it possible to filter somoething out if it has only one tag, but, not if the post has both. For example a lot of flash games have male/male, which I don't want, but it does have others things I do want. One example being COC. It has both male/male, male/female, intsex/x, etc. I would want to play COC, or any other thing that has those tags, but I don't want to have to look at the tag of each post that only has male/male.

Basically, I want to no if there is a way to filter out posts that only have what I don't like, without filtering out posts that have both that, and things I do like.

Put both tags on the same line

will only filter the post if both male and solo are present on the post.

You should peek through the blacklist help page, it goes into more detail and has additional features.

https://e621.net/help/show/blacklist

Yes, you can use -tags in blacklists to exclude results that include the - tag. For instance, male -female , on one line, with blacklist all posts tagged male but, in those results, will exclude any that were tagged female as well.

So your blacklist should look like, if I am understanding you correctly:

Male solo
Male/male -male/female
Male/male -intersex/male

This should get you the same results.