Lafcadio said:
Former, generally. As far as I'm aware, words like E621 and AK47 usually get pronounced with long vowels and long consonants. "Long" means the pronunciation is longer, and also similar to their name: "A" is エイ instead of ア, "E" is イー instead of エ, and "K" is ケー instead of ク or キ. That said, 「エシックス」 would totally make sense if we were talking about, like, a Square Enix character.

Enix ... Ahh shoot ... - post #2778515 - That was the most simple way to think about it...！
I thought esix and e6/E6 would be read differently, but actually the same, alright, Thank you.　And now I understand the essence of "餅は餅屋"
(( Considering pronunciation, エシックス will be chosen when I introduce him to Jpn-people？ ))

Kurogi_FoxSIV said:
Enix ... Ahh shoot ... - post #2778515 - That was the most simple way to think about it...！
I thought esix and e6/E6 would be read differently, but actually the same, alright, Thank you.　And now I understand the essence of "餅は餅屋"
(( Considering pronunciation, エシックス will be chosen when I introduce him to Jpn-people？ ))

i think イーシックス would be best. sorry for the confusion. welcome to e621 by the way!